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Title: SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation

Highlights: • SAMHD1 expression level is down regulated in lung adenocarcinoma. • The promoter of SAMHD1 is methylated in lung adenocarcinoma. • Over expression of SAMHD1 inhibits the proliferation of lung cancer cells. - Abstract: The function of dNTP hydrolase SAMHD1 as a viral restriction factor to inhibit the replication of several viruses in human immune cells was well established. However, its regulation and function in lung cancer have been elusive. Here, we report that SAMHD1 is down regulated both on protein and mRNA levels in lung adenocarcinoma compared to adjacent normal tissue. We also found that SAMHD1 promoter is highly methylated in lung adenocarcinoma, which may inhibit its gene expression. Furthermore, over expression of the SAMHD1 reduces dNTP level and inhibits the proliferation of lung tumor cells. These results reveal the regulation and function of SAMHD1 in lung cancer, which is important for the proliferation of lung tumor cells.
Authors:
 [1] ;  [2] ;  [2] ;  [2] ;  [2]
  1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032 (China)
  2. Department of Thoracic Surgery, The Huadong Hospital, Fudan University, Shanghai 200040 (China)
Publication Date:
OSTI Identifier:
22416855
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 455; Journal Issue: 3-4; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; CARCINOMAS; CELL PROLIFERATION; COMPARATIVE EVALUATIONS; GENES; HUMAN POPULATIONS; LUNGS; MESSENGER-RNA; METHYLATION; PROMOTERS; PROTEINS; TUMOR CELLS; VIRUSES