skip to main content

SciTech ConnectSciTech Connect

Title: The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells

Highlights: • Dendrogenin A and B are new aminoalkyl oxysterols. • Dendrogenins stimulated neural stem cells proliferation. • Dendrogenins induce neuronal outgrowth from neurospheres. • Dendrogenins provide new therapeutic options for neurodegenerative disorders. - Abstract: Dendrogenin A (DDA) and dendrogenin B (DDB) are new aminoalkyl oxysterols which display re-differentiation of tumor cells of neuronal origin at nanomolar concentrations. We analyzed the influence of dendrogenins on adult mice neural stem cell proliferation, sphere formation and differentiation. DDA and DDB were found to have potent proliferative effects in neural stem cells. Additionally, they induce neuronal outgrowth from neurospheres during in vitro cultivation. Taken together, our results demonstrate a novel role for dendrogenins A and B in neural stem cell proliferation and differentiation which further increases their likely importance to compensate for neuronal cell loss in the brain.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [3] ;  [3] ;  [6] ;  [3] ;  [3]
  1. Department of Neuroscience, Karolinska Institute, Stockholm (Sweden)
  2. Affichem, Toulouse (France)
  3. (France)
  4. Department of Public Health and Caring Sciences, Uppsala University, Uppsala (Sweden)
  5. Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Uppsala (Sweden)
  6. INSERM UMR 1037, Team “Sterol Metabolism and Therapeutic Innovations in Oncology”, Cancer Research Center of Toulouse, F-31052 Toulouse (France)
Publication Date:
OSTI Identifier:
22416368
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 446; Journal Issue: 3; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ADULTS; ALKALOIDS; BRAIN; CELL PROLIFERATION; CONCENTRATION RATIO; CULTIVATION; IN VITRO; MICE; STEM CELLS; STEROLS; TUMOR CELLS