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Title: miR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151

Highlights: • miR-22 was decreased in GC tissue samples and cell lines. • miR-22 suppressed GC cell growth and motility in vitro. • CD151 was a direct target of miR-22. • miR-22 suppressed GC cell growth and motility by inhibiting CD151. - Abstract: Gastric cancer (GC) is the second common cause of cancer-related death worldwide. microRNAs (miRNAs) play important roles in the carcinogenesis of GC. Here, we found that miR-22 was significantly decreased in GC tissue samples and cell lines. Ectopic overexpression of miR-22 remarkably suppressed cell proliferation and colony formation of GC cells. Moreover, overexpression of miR-22 significantly suppressed migration and invasion of GC cells. CD151 was found to be a target of miR-22. Furthermore, overexpression of CD151 significantly attenuated the tumor suppressive effect of miR-22. Taken together, miR-22 might suppress GC cells growth and motility partially by inhibiting CD151.
Authors:
 [1] ;  [1] ; ; ;  [2] ;  [3]
  1. Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060 (China)
  2. Department of Gastroenterology, Wuchang Hospital of Wuhan City, Wuhan 430063 (China)
  3. Department of Neurology, Pu Ai Hospital of Wuhan City, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430034 (China)
Publication Date:
OSTI Identifier:
22416295
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 445; Journal Issue: 1; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; CARCINOGENESIS; CELL PROLIFERATION; COLONY FORMATION; DEATH; IN VITRO; MIGRATION; NEOPLASMS; RNA