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Title: Surface coating for prevention of metallic seed migration in tissues

Abstract

Purpose: In radiotherapy, metallic implants often detach from their deposited sites and migrate to other locations. This undesirable migration could cause inadequate dose coverage for permanent brachytherapy and difficulties in image-guided radiation delivery for patients. To prevent migration of implanted seeds, the authors propose a potential strategy to use a biocompatible and tissue-adhesive material called polydopamine. Methods: In this study, nonradioactive dummy seeds that have the same geometry and composition as commercial I-125 seeds were coated in polydopamine. Using scanning electron microscopy and x-ray photoelectron spectroscopy, the surface of the polydopamine-coated and noncoated seeds was characterized. The detachment stress between the two types of seeds and the tissue was measured. The efficacy of polydopamine-coated seed was investigated through in vitro migration tests by tracing the seed location after tissue implantation and shaking for given times. The cytotoxicity of the polydopamine coating was also evaluated. Results: The results of the coating characterization have shown that polydopamine was successfully coated on the surface of the seeds. In the adhesion test, the polydopamine-coated seeds had 2.1-fold greater detachment stress than noncoated seeds. From the in vitro test, it was determined that the polydopamine-coated seed migrated shorter distances than the noncoated seed. This differencemore » was increased with a greater length of time after implantation. Conclusions: The authors suggest that polydopamine coating is an effective technique to prevent migration of implanted seeds, especially for permanent prostate brachytherapy.« less

Authors:
;  [1]; ;  [2];  [3];  [4];  [1]
  1. Program in Biomedical Radiation Sciences, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742 (Korea, Republic of)
  2. Interdisciplinary Program in Bioengineering, Seoul National University College of Engineering, Seoul 151-742 (Korea, Republic of)
  3. Hanaro Applications Research, Korea Atomic Energy Research Institute, Daejeon 305-353 (Korea, Republic of)
  4. Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270 (Korea, Republic of)
Publication Date:
OSTI Identifier:
22413577
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BRACHYTHERAPY; IMPLANTS; IN VITRO; IODINE 125; PATIENTS; PROSTATE; SCANNING ELECTRON MICROSCOPY; SURFACE COATING; TOXICITY; X-RAY PHOTOELECTRON SPECTROSCOPY

Citation Formats

Lee, Hyunseok, Park, Jong In, Lee, Won Seok, Park, Min, Son, Kwang-Jae, Bang, Young-bong, Choy, Young Bin, E-mail: ybchoy@snu.ac.kr, E-mail: sye@snu.ac.kr, Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 110-744, Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 110-744, Ye, Sung-Joon, Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, and Department of Radiation Oncology, Seoul National University Hospital, Seoul 110-744. Surface coating for prevention of metallic seed migration in tissues. United States: N. p., 2015. Web. doi:10.1118/1.4919445.
Lee, Hyunseok, Park, Jong In, Lee, Won Seok, Park, Min, Son, Kwang-Jae, Bang, Young-bong, Choy, Young Bin, E-mail: ybchoy@snu.ac.kr, E-mail: sye@snu.ac.kr, Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 110-744, Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 110-744, Ye, Sung-Joon, Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, & Department of Radiation Oncology, Seoul National University Hospital, Seoul 110-744. Surface coating for prevention of metallic seed migration in tissues. United States. https://doi.org/10.1118/1.4919445
Lee, Hyunseok, Park, Jong In, Lee, Won Seok, Park, Min, Son, Kwang-Jae, Bang, Young-bong, Choy, Young Bin, E-mail: ybchoy@snu.ac.kr, E-mail: sye@snu.ac.kr, Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 110-744, Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 110-744, Ye, Sung-Joon, Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, and Department of Radiation Oncology, Seoul National University Hospital, Seoul 110-744. 2015. "Surface coating for prevention of metallic seed migration in tissues". United States. https://doi.org/10.1118/1.4919445.
@article{osti_22413577,
title = {Surface coating for prevention of metallic seed migration in tissues},
author = {Lee, Hyunseok and Park, Jong In and Lee, Won Seok and Park, Min and Son, Kwang-Jae and Bang, Young-bong and Choy, Young Bin, E-mail: ybchoy@snu.ac.kr, E-mail: sye@snu.ac.kr and Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 110-744 and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 110-744 and Ye, Sung-Joon and Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270 and Department of Radiation Oncology, Seoul National University Hospital, Seoul 110-744},
abstractNote = {Purpose: In radiotherapy, metallic implants often detach from their deposited sites and migrate to other locations. This undesirable migration could cause inadequate dose coverage for permanent brachytherapy and difficulties in image-guided radiation delivery for patients. To prevent migration of implanted seeds, the authors propose a potential strategy to use a biocompatible and tissue-adhesive material called polydopamine. Methods: In this study, nonradioactive dummy seeds that have the same geometry and composition as commercial I-125 seeds were coated in polydopamine. Using scanning electron microscopy and x-ray photoelectron spectroscopy, the surface of the polydopamine-coated and noncoated seeds was characterized. The detachment stress between the two types of seeds and the tissue was measured. The efficacy of polydopamine-coated seed was investigated through in vitro migration tests by tracing the seed location after tissue implantation and shaking for given times. The cytotoxicity of the polydopamine coating was also evaluated. Results: The results of the coating characterization have shown that polydopamine was successfully coated on the surface of the seeds. In the adhesion test, the polydopamine-coated seeds had 2.1-fold greater detachment stress than noncoated seeds. From the in vitro test, it was determined that the polydopamine-coated seed migrated shorter distances than the noncoated seed. This difference was increased with a greater length of time after implantation. Conclusions: The authors suggest that polydopamine coating is an effective technique to prevent migration of implanted seeds, especially for permanent prostate brachytherapy.},
doi = {10.1118/1.4919445},
url = {https://www.osti.gov/biblio/22413577}, journal = {Medical Physics},
issn = {0094-2405},
number = 6,
volume = 42,
place = {United States},
year = {Mon Jun 15 00:00:00 EDT 2015},
month = {Mon Jun 15 00:00:00 EDT 2015}
}