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Title: Dewetting transition assisted clearance of (NFGAILS) amyloid fibrils from cell membranes by graphene

Clearance of partially ordered oligomers and monomers deposited on cell membrane surfaces is believed to be an effective route to alleviate many potential protein conformational diseases (PCDs). With large-scale all-atom molecular dynamics simulations, here we show that graphene nanosheets can easily and quickly win a competitive adsorption of human islet amyloid polypeptides (hIAPP{sub 22-28}) NFGAILS and associated fibrils against cell membrane, due to graphene's unique two-dimensional, highly hydrophobic surface with its all-sp{sup 2} hybrid structure. A nanoscale dewetting transition was observed at the interfacial region between the fibril (originally deposited on the membrane) and the graphene nanosheet, which significantly assisted the adsorption of fibrils onto graphene from the membrane. The π–π stacking interaction between Phe23 and graphene played a crucial role, providing the driving force for the adsorption at the graphene surface. This study renders new insight towards the importance of water during the interactions between amyloid peptides, the phospholipidic membrane, and graphene, which might shed some light on future developments of graphene-based nanomedicine for preventing/curing PCDs like type II diabetes mellitus.
Authors:
; ;  [1] ;  [2] ;  [3] ;  [1] ;  [4] ;  [4]
  1. Institute of Quantitative Biology and Medicine, SRMP and RAD-X, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123 (China)
  2. Bio-X Lab, Department of Physics, Zhejiang University, Hangzhou 310027 (China)
  3. IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598 (United States)
  4. (United States)
Publication Date:
OSTI Identifier:
22413313
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Chemical Physics; Journal Volume: 141; Journal Issue: 22; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ADSORPTION; CELL MEMBRANES; DEPOSITS; DIABETES MELLITUS; GRAPHENE; HYBRIDIZATION; INTERACTIONS; MOLECULAR DYNAMICS METHOD; MONOMERS; NANOSTRUCTURES; POLYPEPTIDES; SIMULATION; SURFACES; TWO-DIMENSIONAL SYSTEMS