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Title: Full-direct method for imaging pharmacokinetic parameters in dynamic fluorescence molecular tomography

Images of pharmacokinetic parameters (also known as parametric images) in dynamic fluorescence molecular tomography (FMT) can provide three-dimensional metabolic information for biological studies and drug development. However, the ill-posed nature of FMT and the high temporal variation of fluorophore concentration together make it difficult to obtain accurate parametric images in small animals in vivo. In this letter, we present a method to directly reconstruct the parametric images from the boundary measurements based on hybrid FMT/X-ray computed tomography (XCT) system. This method can not only utilize structural priors obtained from the XCT system to mitigate the ill-posedness of FMT but also make full use of the temporal correlations of boundary measurements to model the high temporal variation of fluorophore concentration. The results of numerical simulation and mouse experiment demonstrate that the proposed method leads to significant improvements in the reconstruction quality of parametric images.
Authors:
 [1] ;  [2] ; ; ;  [1] ;  [3] ;  [1] ;  [2]
  1. Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084 (China)
  2. (China)
  3. China Institute of Sport Science, Beijing 100061 (China)
Publication Date:
OSTI Identifier:
22412680
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 106; Journal Issue: 8; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BIOMEDICAL RADIOGRAPHY; COMPUTERIZED SIMULATION; CONCENTRATION RATIO; CORRELATIONS; FLUORESCENCE; IMAGES; IN VIVO; MICE; PHOTON COMPUTED TOMOGRAPHY; VARIATIONS; X RADIATION