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Title: Effects of microstructure and water on the electrical potentials in bone induced by ultrasound irradiation

The healing mechanism of bone fractures by low intensity pulse ultrasound is yet to be fully understood. There have been many discussions regarding how the high frequency dynamic stress can stimulate numerous cell types through various pathways. As one possible initial process of this mechanism, we focus on the piezoelectricity of bone and demonstrate that bone can generate electrical potentials by ultrasound irradiation in the MHz range. We have fabricated ultrasonic bone transducers using bovine cortical bone as the piezoelectric device. The ultrasonically induced electrical potentials in the transducers change as a function of time during immersed ultrasonic pulse measurements and become stable when the bone is fully wet. In addition, the magnitude of the induced electrical potentials changes owing to the microstructure in the cortical bone. The potentials of transducers with haversian structure bone are higher than those of plexiform structure bone, which informs about the effects of bone microstructure on the piezoelectricity.
Authors:
; ; ;  [1] ;  [2] ;  [3]
  1. Wave Electronics Research Center, Laboratory of Ultrasonic Electronics, Doshisha University, 1-3, Tatara Miyakodani, Kyotanabe, Kyoto 610-0321 (Japan)
  2. Underwater Technology Collaborative Research Center, Institute of Industrial Science, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8505 (Japan)
  3. Graduate School of Engineering, Nagoya Institute of Technology, Gokiso cho, Showa-ku, Nagoya 466-8555 (Japan)
Publication Date:
OSTI Identifier:
22412670
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 106; Journal Issue: 7; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; BONE FRACTURES; ELECTRIC POTENTIAL; HEALING; IRRADIATION; MHZ RANGE; MICROSTRUCTURE; PIEZOELECTRICITY; STRESSES; TIME DEPENDENCE; TRANSDUCERS; ULTRASONIC WAVES