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Title: SU-F-18C-02: Evaluations of the Noise Power Spectrum of a CT Iterative Reconstruction Technique for Radiation Therapy

Purpose: To quantitatively assess the noise power spectrum (NPS) of the new, commercially released CT iterative reconstruction technique, iDose{sup 4} from Philips, to compare it with filtered back-projection techniques (FBP), and to provide clinical practice suggestions for radiation therapy. Methods: A uniform phantom was CT imaged with 120kVp tube potential over a range of mAs (250-3333). The image sets were reconstructed using two reconstruction algorithms (FBP and iDose{sup 4} with noise reduction levels 1, 3, and 6) and three reconstruction filters (standard B, smooth A, and sharp C), after which NPS variations were analyzed and compared on region of interest (ROI) sizes (16×16 to 128×128 pixels), ROI radii (0–65 mm), reconstruction algorithms, reconstruction filters, and mAs. Results: The NPS magnitude and shape depended considerably on ROI size and location for both reconstruction algorithms. Regional noise variance became more stationary as ROI size decreased, minimizing NPS artifacts. The optimal 32×32-pixel ROI size balanced the trade-off between stationary noise and adequate sampling. NPS artifacts were greatest at the center of reconstruction space and decreased with increasing ROI distance from the center. The optimal ROI position was located near the phantom's radial midpoint (∼40mm). For sharper filters, the NPS magnitude and the maximummore » magnitude frequency increased. Higher dose scans yielded lower NPS magnitudes for both reconstruction algorithms and all filters. Compared to FBP, the iDose{sup 4} algorithm reduced the NPS magnitude while preferentially reducing noise at mid-range spatial frequencies, altering noise texture. This reduction was more significant with increasing iDose{sup 4} noise reduction level. Conclusion: Compared to pixel standard deviation, NPS has greater clinical potential for task-based image quality assessment, describing both the magnitude and spatial frequency characteristics of image noise. While iDose{sup 4} reduces the NPS magnitude more dramatically than FBP, further studies are needed to assess the impacts of noise texture alteration on its clinical usage.« less
 [1] ;  [2] ; ; ; ;  [3]
  1. University of Missouri, Columbia, MO (United States)
  2. (United States)
  3. Washington University School of Medicine, Saint Louis, MO (United States)
Publication Date:
OSTI Identifier:
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 41; Journal Issue: 6; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States