skip to main content

SciTech ConnectSciTech Connect

Title: Graphene oxide-Fe{sub 3}O{sub 4} nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging

The potential of graphene oxide–Fe{sub 3}O{sub 4} nanoparticle (GO-Fe{sub 3}O{sub 4}) composite as an image contrast enhancing material in magnetic resonance imaging has been investigated. Proton relaxivity values were obtained in three different homogeneous dispersions of GO-Fe{sub 3}O{sub 4} composites synthesized by precipitating Fe{sub 3}O{sub 4} nanoparticles in three different reaction mixtures containing 0.01 g, 0.1 g, and 0.2 g of graphene oxide. A noticeable difference in proton relaxivity values was observed between the three cases. A comprehensive structural and magnetic characterization revealed discrete differences in the extent of reduction of the graphene oxide and spacing between the graphene oxide sheets in the three composites. The GO-Fe{sub 3}O{sub 4} composite framework that contained graphene oxide with least extent of reduction of the carboxyl groups and largest spacing between the graphene oxide sheets provided the optimum structure for yielding a very high transverse proton relaxivity value. It was found that the GO-Fe{sub 3}O{sub 4} composites possessed good biocompatibility with normal cell lines, whereas they exhibited considerable toxicity towards breast cancer cells.
Authors:
;  [1] ; ;  [2] ;  [3]
  1. Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India)
  2. Medical Imaging Research Centre, Dayananda Sagar Institutions, Bangalore 560078 (India)
  3. Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012 (India)
Publication Date:
OSTI Identifier:
22402882
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Applied Physics; Journal Volume: 117; Journal Issue: 15; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES; CARBON OXIDES; COMPOSITE MATERIALS; FERRITES; GRAPHENE; IMAGES; IRON OXIDES; MIXTURES; NANOPARTICLES; NEOPLASMS; NMR IMAGING; PRECIPITATION; PROTONS; SHEETS