Graphene oxide-Fe{sub 3}O{sub 4} nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging
Abstract
The potential of graphene oxide–Fe{sub 3}O{sub 4} nanoparticle (GO-Fe{sub 3}O{sub 4}) composite as an image contrast enhancing material in magnetic resonance imaging has been investigated. Proton relaxivity values were obtained in three different homogeneous dispersions of GO-Fe{sub 3}O{sub 4} composites synthesized by precipitating Fe{sub 3}O{sub 4} nanoparticles in three different reaction mixtures containing 0.01 g, 0.1 g, and 0.2 g of graphene oxide. A noticeable difference in proton relaxivity values was observed between the three cases. A comprehensive structural and magnetic characterization revealed discrete differences in the extent of reduction of the graphene oxide and spacing between the graphene oxide sheets in the three composites. The GO-Fe{sub 3}O{sub 4} composite framework that contained graphene oxide with least extent of reduction of the carboxyl groups and largest spacing between the graphene oxide sheets provided the optimum structure for yielding a very high transverse proton relaxivity value. It was found that the GO-Fe{sub 3}O{sub 4} composites possessed good biocompatibility with normal cell lines, whereas they exhibited considerable toxicity towards breast cancer cells.
- Authors:
-
- Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India)
- Medical Imaging Research Centre, Dayananda Sagar Institutions, Bangalore 560078 (India)
- Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012 (India)
- Publication Date:
- OSTI Identifier:
- 22402882
- Resource Type:
- Journal Article
- Journal Name:
- Journal of Applied Physics
- Additional Journal Information:
- Journal Volume: 117; Journal Issue: 15; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0021-8979
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES; CARBON OXIDES; COMPOSITE MATERIALS; FERRITES; GRAPHENE; IMAGES; IRON OXIDES; MIXTURES; NANOPARTICLES; NEOPLASMS; NMR IMAGING; PRECIPITATION; PROTONS; SHEETS
Citation Formats
Venkatesha, N., Srivastava, Chandan, Poojar, Pavan, Geethanath, Sairam, and Qurishi, Yasrib. Graphene oxide-Fe{sub 3}O{sub 4} nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging. United States: N. p., 2015.
Web. doi:10.1063/1.4918605.
Venkatesha, N., Srivastava, Chandan, Poojar, Pavan, Geethanath, Sairam, & Qurishi, Yasrib. Graphene oxide-Fe{sub 3}O{sub 4} nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging. United States. https://doi.org/10.1063/1.4918605
Venkatesha, N., Srivastava, Chandan, Poojar, Pavan, Geethanath, Sairam, and Qurishi, Yasrib. 2015.
"Graphene oxide-Fe{sub 3}O{sub 4} nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging". United States. https://doi.org/10.1063/1.4918605.
@article{osti_22402882,
title = {Graphene oxide-Fe{sub 3}O{sub 4} nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging},
author = {Venkatesha, N. and Srivastava, Chandan and Poojar, Pavan and Geethanath, Sairam and Qurishi, Yasrib},
abstractNote = {The potential of graphene oxide–Fe{sub 3}O{sub 4} nanoparticle (GO-Fe{sub 3}O{sub 4}) composite as an image contrast enhancing material in magnetic resonance imaging has been investigated. Proton relaxivity values were obtained in three different homogeneous dispersions of GO-Fe{sub 3}O{sub 4} composites synthesized by precipitating Fe{sub 3}O{sub 4} nanoparticles in three different reaction mixtures containing 0.01 g, 0.1 g, and 0.2 g of graphene oxide. A noticeable difference in proton relaxivity values was observed between the three cases. A comprehensive structural and magnetic characterization revealed discrete differences in the extent of reduction of the graphene oxide and spacing between the graphene oxide sheets in the three composites. The GO-Fe{sub 3}O{sub 4} composite framework that contained graphene oxide with least extent of reduction of the carboxyl groups and largest spacing between the graphene oxide sheets provided the optimum structure for yielding a very high transverse proton relaxivity value. It was found that the GO-Fe{sub 3}O{sub 4} composites possessed good biocompatibility with normal cell lines, whereas they exhibited considerable toxicity towards breast cancer cells.},
doi = {10.1063/1.4918605},
url = {https://www.osti.gov/biblio/22402882},
journal = {Journal of Applied Physics},
issn = {0021-8979},
number = 15,
volume = 117,
place = {United States},
year = {Tue Apr 21 00:00:00 EDT 2015},
month = {Tue Apr 21 00:00:00 EDT 2015}
}