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Title: miR-92a family and their target genes in tumorigenesis and metastasis

The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: • Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. • The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. • Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.
Authors:
 [1] ;  [2] ; ;  [1] ;  [3] ;  [4] ;  [5] ;  [5]
  1. Department of Pathophysiology, Basic Medical Science of Dalian Medical University, Dalian 116044 (China)
  2. (China)
  3. Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian 116044 (China)
  4. College of Pharmacy, Dalian Medical University Cancer Center, Dalian 116044 (China)
  5. Department of Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027 (China)
Publication Date:
OSTI Identifier:
22395882
Resource Type:
Journal Article
Resource Relation:
Journal Name: Experimental Cell Research; Journal Volume: 323; Journal Issue: 1; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; APOPTOSIS; ARSENIC 92; CELL PROLIFERATION; EVOLUTION; GENES; METASTASES; NEOPLASMS; REVIEWS