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Title: Multimodal diagnosis and visualisation of oncologic pathologies

The combined application of optical coherence tomography, Raman and autofluorescence spectroscopy of biotissues for the analysis of human malignant neoplasms is demonstrated. Rapid investigation of vast biotissue regions (at the scale of entire organs) is possible using the autofluorescence response. After selection of possible zones of pathologies one can visualise the neoplasm topology in the zone of interest with micron precision by using optical coherence tomography. In the case of suspecting the malignancy the analysis of the biotissue Raman spectrum is carried out that allows identification of the neoplasm type with the sensitivity and specificity ∼85%. An experimental scheme is proposed with the combined use of the abovementioned methods, which is a prototype of the medical system for complex analysis of neoplasms. (laser biophotonics)
Authors:
; ; ; ;  [1] ; ;  [2]
  1. S.P. Korolev Samara State Aerospace University, Samara (Russian Federation)
  2. Samara State Medical University, Samara (Russian Federation)
Publication Date:
OSTI Identifier:
22395821
Resource Type:
Journal Article
Resource Relation:
Journal Name: Quantum Electronics (Woodbury, N.Y.); Journal Volume: 44; Journal Issue: 8; Other Information: Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; DIAGNOSIS; FLUORESCENCE; NEOPLASMS; ORGANS; PATHOLOGY; RAMAN SPECTRA; SENSITIVITY; SPECIFICITY; TOMOGRAPHY