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Title: Note: A microfluidic freezer based on evaporative cooling of atomized aqueous microdroplets

We report for the first time water-based evaporative cooling integrated into a microfluidic chip for temperature control and freezing of biological solution. We opt for water as a nontoxic, effective refrigerant. Aqueous solutions are atomized in our device and evaporation of microdroplets under vacuum removes heat effectively. We achieve rapid cooling (−5.1 °C/s) and a low freezing temperature (−14.1 °C). Using this approach, we demonstrate freezing of deionized water and protein solution. Our simple, yet effective cooling device may improve many microfluidic applications currently relying on external power-hungry instruments for cooling and freezing.
Authors:
;  [1] ;  [2]
  1. Department of Mechanical Engineering, Myongji University, Yongin-si, Gyeonggi-do 449-728 (Korea, Republic of)
  2. Department of Chemical Engineering, Hongik University, Mapo-gu, Seoul 121-791 (Korea, Republic of)
Publication Date:
OSTI Identifier:
22392337
Resource Type:
Journal Article
Resource Relation:
Journal Name: Review of Scientific Instruments; Journal Volume: 86; Journal Issue: 1; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; AQUEOUS SOLUTIONS; EVAPORATION; EVAPORATIVE COOLING; FREEZERS; FREEZING; HEAT; REFRIGERANTS; TEMPERATURE CONTROL; WATER