Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications
Abstract
Highly porous three-dimensional polylactide (PLA) scaffolds were obtained from PLA incorporated with different amounts of chitosan-modified montmorillonite (CS-MMT), through solvent casting and particulate leaching method. The processed scaffolds were tested in vitro for their possible application in bone tissue engineering. Scaffolds were characterized by Focused Ion Beam Scanning Electron Microscopy (FIB SEM), Fourier Transform Infra-Red (FTIR), and X-Ray Diffraction (XRD) to study their structure and intermolecular interactions. Bioresorbability tests in simulated body fluid (pH 7.4) were conducted to assess the response of the scaffolds in a simulated physiological condition. The FIB SEM images of the scaffolds showed a porous architecture with gradual change in morphology with increasing CS-MMT concentration. FTIR analysis revealed the presence of both PLA and CS-MMT particles on the surface of the scaffolds. XRD showed that the crystalline unit cell type was the same for all the scaffolds, and crystallinity decreased with an increase in CS-MMT concentration. The scaffolds were found to be bioresorbable, with rapid bioresorbability on the scaffolds with a high CS-MMT concentration.
- Authors:
-
- Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028 (South Africa)
- Publication Date:
- OSTI Identifier:
- 22391860
- Resource Type:
- Journal Article
- Journal Name:
- AIP Conference Proceedings
- Additional Journal Information:
- Journal Volume: 1664; Journal Issue: 1; Conference: PPS-30: 30. International Conference of the Polymer Processing Society, Cleveland, OH (United States), 6-12 Jun 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; AMINO ACIDS; BODY FLUIDS; BONE TISSUES; CASTING; CONCENTRATION RATIO; FOURIER TRANSFORMATION; INFRARED SPECTRA; ION BEAMS; MONTMORILLONITE; MORPHOLOGY; OLIGOSACCHARIDES; PARTICLES; POROUS MATERIALS; SCANNING ELECTRON MICROSCOPY; X-RAY DIFFRACTION
Citation Formats
Mkhabela, Vuyiswa J., Ray, Suprakas Sinha, and DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001. Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications. United States: N. p., 2015.
Web. doi:10.1063/1.4918444.
Mkhabela, Vuyiswa J., Ray, Suprakas Sinha, & DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001. Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications. United States. https://doi.org/10.1063/1.4918444
Mkhabela, Vuyiswa J., Ray, Suprakas Sinha, and DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001. 2015.
"Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications". United States. https://doi.org/10.1063/1.4918444.
@article{osti_22391860,
title = {Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications},
author = {Mkhabela, Vuyiswa J. and Ray, Suprakas Sinha and DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001},
abstractNote = {Highly porous three-dimensional polylactide (PLA) scaffolds were obtained from PLA incorporated with different amounts of chitosan-modified montmorillonite (CS-MMT), through solvent casting and particulate leaching method. The processed scaffolds were tested in vitro for their possible application in bone tissue engineering. Scaffolds were characterized by Focused Ion Beam Scanning Electron Microscopy (FIB SEM), Fourier Transform Infra-Red (FTIR), and X-Ray Diffraction (XRD) to study their structure and intermolecular interactions. Bioresorbability tests in simulated body fluid (pH 7.4) were conducted to assess the response of the scaffolds in a simulated physiological condition. The FIB SEM images of the scaffolds showed a porous architecture with gradual change in morphology with increasing CS-MMT concentration. FTIR analysis revealed the presence of both PLA and CS-MMT particles on the surface of the scaffolds. XRD showed that the crystalline unit cell type was the same for all the scaffolds, and crystallinity decreased with an increase in CS-MMT concentration. The scaffolds were found to be bioresorbable, with rapid bioresorbability on the scaffolds with a high CS-MMT concentration.},
doi = {10.1063/1.4918444},
url = {https://www.osti.gov/biblio/22391860},
journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1664,
place = {United States},
year = {Fri May 22 00:00:00 EDT 2015},
month = {Fri May 22 00:00:00 EDT 2015}
}