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Title: Production of {sup 177}Lu, a potential radionuclide for diagnostic and therapeutic applications

{sup 177g}Lu (T{sub 1/2}=6.647d; E{sub β{sup −max}}=498.3KeV, I{sub β{sup −total}}=100%; E{sub γ} = 112.9498 keV, I{sub γ} = 6.17%; E{sub γ} = 208.3662 keV, I {sub γ} = 10.36%) is widely used in many clinical procedures due to its excellent decay characteristics. Production cross-sections of the {sup nat}Yb(d,x){sup 177g}Lu reactions have been measured from a 24-MeV deuteron energy down to the threshold by using a stacked-foil activation technique combined with high resolution γ-ray spectrometry. An overall good agreement is found with some of the earlier measurements, whereas a partial agreement is obtained with the theoretical data extracted from the TENDL-2013 library. Physical thick target yield for the {sup 177g}Lu radionuclide was deduced using the measured cross-sections. The deduced yield curves indicate that a low energy (<11 MeV) cyclotron and a highly enriched {sup 176}Yb target could be used to obtain {sup 177g}Lu with negligible impurity from {sup 177m}Lu.
Authors:
;  [1] ;  [2]
  1. Department of Physics, University of Malaya, 50603 Kuala Lumpur (Malaysia)
  2. Nishina Center for Accelerator-Based Science, RIKEN, Wako, Saitama 351-0198 (Japan)
Publication Date:
OSTI Identifier:
22391551
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1657; Journal Issue: 1; Conference: PERFIK 2014: National Physics Conference 2014, Kuala Lumpur (Malaysia), 18-19 Nov 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
07 ISOTOPES AND RADIATION SOURCES; CROSS SECTIONS; DEUTERON REACTIONS; DEUTERONS; DIAGRAMS; GAMMA SPECTROSCOPY; ISOTOPE PRODUCTION; KEV RANGE; LUTETIUM 177; MEV RANGE; NUCLEAR DECAY; NUCLEAR REACTION YIELD; RESOLUTION; YTTERBIUM 172 TARGET; YTTERBIUM 173 TARGET; YTTERBIUM 174 TARGET; YTTERBIUM 176