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Title: Enhancement of radiation cytotoxicity by gold nanoparticles in MCF-7 breast cancer cell lines

Therapy combined with metallic nanoparticles is a new way to treat cancer, in which gold nanoparticles (AuNPs) are injected through intravenous administration and bound to tumor sites. Radiotherapy aims to deliver a high therapeutic dose of ionizing radiation to the tumor without exceeding normal tissue tolerance. The use of AuNPs which is a high-atomic-number (Z) material in radiotherapy will provide a high probability for photon interaction by photoelectric effect. These provide advantages in terms of radiation dose enhancement. The high linear energy transfer and short range of photoelectric interaction products (photoelectrons, characteristic x-rays, Auger electrons) produce localized dose enhancement of the tumor. In this work, breast cancer cell lines (MCF-7) are seeded in the 96-well plate and were treated with 13 nm AuNPs before they were irradiated with 6 MV and 10 MV photon beam from a medical linear accelerator at various radiation doses. To validate the enhanced killing effect, both with and without AuNPs MCF-7 cells is irradiated simultaneously. By comparison, the results show that AuNPs significantly enhance cancer killing.
Authors:
;  [1] ;  [1] ;  [2] ;  [3] ;  [4]
  1. School of Physics, Universiti Sains Malaysia, 11800, Pulau Pinang (Malaysia)
  2. (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang (Malaysia)
  3. Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang (Malaysia)
  4. (Malaysia)
Publication Date:
OSTI Identifier:
22391528
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1657; Journal Issue: 1; Conference: PERFIK 2014: National Physics Conference 2014, Kuala Lumpur (Malaysia), 18-19 Nov 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
07 ISOTOPES AND RADIATION SOURCES; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ANIMAL TISSUES; COMPARATIVE EVALUATIONS; ELECTRONS; GOLD; IRRADIATION; LET; LINEAR ACCELERATORS; MAMMARY GLANDS; NANOPARTICLES; NEOPLASMS; PHOTOELECTRIC EFFECT; PHOTON BEAMS; PHOTONS; RADIATION DOSES; RADIOTHERAPY; TOLERANCE; TOXICITY; X RADIATION