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Title: A simplified model for dynamics of cell rolling and cell-surface adhesion

We propose a three dimensional model for the adhesion and rolling of biological cells on surfaces. We study cells moving in shear flow above a wall to which they can adhere via specific receptor-ligand bonds based on receptors from selectin as well as integrin family. The computational fluid dynamics are governed by the lattice-Boltzmann method. The movement and the deformation of the cells is described by the immersed boundary method. Both methods are fully coupled by implementing a two-way fluid-structure interaction. The adhesion mechanism is modelled by adhesive bonds including stochastic rules for their creation and rupture. We explore a simplified model with dissociation rate independent of the length of the bonds. We demonstrate that this model is able to resemble the mesoscopic properties, such as velocity of rolling cells.
Authors:
 [1]
  1. Cell-in-fluid Research Group, http://cell-in-fluid.fri.uniza.sk Faculty of Management Science and Informatics, University of Žilina Univerzitná 8215/1, 010 26 Žilina (Slovakia)
Publication Date:
OSTI Identifier:
22391060
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1648; Journal Issue: 1; Conference: ICNAAM-2014: International Conference on Numerical Analysis and Applied Mathematics 2014, Rhodes (Greece), 22-28 Sep 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ADHESION; ADHESIVES; COMPUTERIZED SIMULATION; DEFORMATION; DISSOCIATION; FLUID MECHANICS; FLUID-STRUCTURE INTERACTIONS; LIGANDS; RECEPTORS; ROLLING; RUPTURES; SHEAR; STOCHASTIC PROCESSES; SURFACES; THREE-DIMENSIONAL CALCULATIONS