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Title: Reducing the uncertainties in particle therapy

The use of fundamental Nuclear Physics in Nuclear Medicine has a significant impact in the fight against cancer. Hadrontherapy is an innovative cancer radiotherapy method using nuclear particles (protons, neutrons and ions) for the treatment of early and advanced tumors. The main goal of proton therapy is to deliver high radiation doses to the tumor volume with minimal damage to healthy tissues and organs. The purpose of this work was to investigate the dosimetric errors in clinical proton therapy dose calculation due to the presence of metallic implants in the treatment plan, and to determine the impact of the errors. The results indicate that the errors introduced by the treatment planning systems are higher than 10% in the prediction of the dose at isocenter when the proton beam is passing directly through a metallic titanium alloy implant. In conclusion, we recommend that pencil-beam algorithms not be used when planning treatment for patients with titanium alloy implants, and to consider implementing methods to mitigate the effects of the implants.
Authors:
 [1] ; ; ;  [2]
  1. Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980, Dubna, Moscow Region, Russia and Faculty of Physics, University of Bucharest, Atomistilor Street 405, 077125 Bucharest-Magurele, Ilfov Region (Romania)
  2. Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980, Dubna, Moscow Region (Russian Federation)
Publication Date:
OSTI Identifier:
22390998
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1645; Journal Issue: 1; Conference: Carpathian Summer School of Physics 2014, Sinaia (Romania), 13-26 Jul 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALGORITHMS; ANIMAL TISSUES; NEOPLASMS; NEUTRONS; PATIENTS; PROTON BEAMS; PROTONS; RADIATION DOSES; RADIOTHERAPY; TITANIUM ALLOYS