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Title: A model with competition between the cell lines in leukemia under treatment

The evolution of leukemia is modeled with a delay differential equation model of four cell populations: two populations (healthy and leukemic) ) of stem-like cells involving a larger category consisting of proliferating stem and progenitor cells with self-renew capacity and two populations (healthy and leukemic) of mature cells, considering the competition of healthy vs. leukemic cell populations and three types of division that a stem-like cell can exhibit: self-renew, asymmetric division and differentiation. In the model it is assumed that the treatment acts on the proliferation rate of the leukemic stem cells and on the apoptosis of stem and mature cells. The emphasis in this model is on establishing relevant parameters for chronic and acute manifestations of leukemia. Stability of equilibria is investigated and sufficient conditions for local asymptotic stability will be given using a Lyapunov-Krasovskii functional.
Authors:
; ;  [1]
  1. POLITEHNICA University of Bucharest Department of Mathematics and Informatics Splaiul Independentei 313 RO-060042 Bucharest (Romania)
Publication Date:
OSTI Identifier:
22390773
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1637; Journal Issue: 1; Conference: ICNPAA 2014: 10. International Conference on Mathematical Problems in Engineering, Aerospace and Sciences, Narvik (Norway), 15-18 Jul 2014; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; APOPTOSIS; ASYMMETRY; ASYMPTOTIC SOLUTIONS; CAPACITY; DIFFERENTIAL EQUATIONS; EQUILIBRIUM; FUNCTIONALS; LEUKEMIA; LYAPUNOV METHOD; STABILITY; STEM CELLS