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Title: Conducting polymer functionalized single-walled carbon nanotube based chemiresistive biosensor for the detection of human cardiac myoglobin

We report the fabrication of a single-walled carbon nanotube (SWNT) based ultrasensitive label-free chemiresistive biosensor for the detection of human cardiac biomarker, myoglobin (Ag-cMb). Poly(pyrrole-co-pyrrolepropylic acid) with pendant carboxyl groups was electrochemically deposited on electrophoretically aligned SWNT channel, as a conducting linker, for biomolecular immobilization of highly specific cardiac myoglobin antibody. The device was characterized by scanning electron microscopy, source-drain current-voltage (I-V), and charge-transfer characteristic studies. The device exhibited a linear response with a change in conductance in SWNT channel towards the target, Ag-cMb, over the concentration range of 1.0 to 1000 ng ml{sup −1} with a sensitivity of ∼118% per decade with high specificity.
Authors:
 [1] ;  [2] ;  [3] ; ;  [1] ;  [4]
  1. CSIR-National Physical Laboratory, Dr. K. S. Krishnan Road, New Delhi 110012 (India)
  2. (India)
  3. Department of Physics, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi 110025 (India)
  4. Department of Chemical and Environmental Engineering, University of California, Riverside, California 92521 (United States)
Publication Date:
OSTI Identifier:
22350928
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 105; Journal Issue: 15; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; BIOLOGICAL MARKERS; CARBON NANOTUBES; CONCENTRATION RATIO; CURRENTS; DETECTION; ELECTRIC CONDUCTIVITY; ELECTRIC POTENTIAL; ELECTROCHEMISTRY; EQUIPMENT; MYOGLOBIN; POLYMERS; PYRROLES; SCANNING ELECTRON MICROSCOPY; SENSITIVITY; SPECIFICITY