skip to main content

SciTech ConnectSciTech Connect

Title: Collaborative Computational Project for Electron cryo-Microscopy

The Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) is a new initiative for the structural biology community, following the success of CCP4 for macromolecular crystallography. Progress in supporting the users and developers of cryoEM software is reported. The Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has recently been established. The aims of the project are threefold: to build a coherent cryoEM community which will provide support for individual scientists and will act as a focal point for liaising with other communities, to support practising scientists in their use of cryoEM software and finally to support software developers in producing and disseminating robust and user-friendly programs. The project is closely modelled on CCP4 for macromolecular crystallography, and areas of common interest such as model fitting, underlying software libraries and tools for building program packages are being exploited. Nevertheless, cryoEM includes a number of techniques covering a large range of resolutions and a distinct project is required. In this article, progress so far is reported and future plans are discussed.
Authors:
;  [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7]
  1. Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA (United Kingdom)
  2. European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD (United Kingdom)
  3. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (United Kingdom)
  4. University of London, Malet Street, London WC1E 7HX (United Kingdom)
  5. University of Manchester, Oxford Road, Manchester M13 9PT (United Kingdom)
  6. Science and Technology Facilities Council, Daresbury Laboratory, Warrington WA4 4AD (United Kingdom)
  7. (United Kingdom)
Publication Date:
OSTI Identifier:
22347704
Resource Type:
Journal Article
Resource Relation:
Journal Name: Acta Crystallographica. Section D: Biological Crystallography; Journal Volume: 71; Journal Issue: Pt 1; Other Information: PMCID: PMC4304692; PMID: 25615866; PUBLISHER-ID: gm5035; OAI: oai:pubmedcentral.nih.gov:4304692; Copyright (c) Wood et al. 2015; This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
Denmark
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; COVERINGS; CRYSTALS; ELECTRONS; MICROSCOPY; RESOLUTION