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Title: Development of highly porous scaffolds based on bioactive silicates for dental tissue engineering

Graphical abstract: - Highlights: • Synthesis of an Mg-based glass-ceramic via the sol–gel technique. • The heat treatment of the glass-ceramic promoted the crystallization of akermanite. • Akermanite scaffolds coated with gelatin were successfully fabricated. • An HCAp layer was developed on the surface of all scaffolds after 9 days in SBF. - Abstract: Various scaffolding materials, ceramics and especially Mg-based ceramic materials, including akermanite (Ca{sub 2}MgSi{sub 2}O{sub 7}) and diopside (CaMgSi{sub 2}O{sub 6}), have attracted interest for dental tissue regeneration because of their improved mechanical properties and controllable biodegradation. The aim of the present work was the synthesis of an Mg-based glass-ceramic, which would be used for the construction of workable akermanite scaffolds. The characterization of the synthesized material was performed by Fourier Transform Infrared Spectroscopy (FTIR) X-Ray Diffractometry (XRD) and Scanning Electron Microscopy (SEM). Finally, the apatite forming ability of the scaffolds was assessed by immersion in simulated body fluid. The scaffolds were fabricated by the foam replica technique and were subsequently coated with gelatin to provide a functional surface for increased cell attachment. Finally, SEM microphotographs and FTIR spectra of the scaffolds after immersion in SBF solution indicated the inorganic bioactive character of the scaffolds suitable formore » the intended applications in dental tissue engineering.« less
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [1] ;  [5] ;  [4] ;  [5] ;  [1]
  1. Institute for Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen (Germany)
  2. (Greece)
  3. School of Geology, Aristotle University of Thessaloniki, 54124 Thessaloniki (Greece)
  4. Department of Fixed Prosthodontics, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki (Greece)
  5. Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki (Greece)
Publication Date:
OSTI Identifier:
22341849
Resource Type:
Journal Article
Resource Relation:
Journal Name: Materials Research Bulletin; Journal Volume: 49; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; ABSORPTION SPECTROSCOPY; CERAMICS; CRYSTALLIZATION; DIOPSIDE; FOURIER TRANSFORMATION; HEAT TREATMENTS; INFRARED SPECTRA; MECHANICAL PROPERTIES; POROUS MATERIALS; REPLICA TECHNIQUES; SCANNING ELECTRON MICROSCOPY; SIMULATION; SOL-GEL PROCESS; SYNTHESIS; X-RAY DIFFRACTION