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Title: A robust ligand exchange approach for preparing hydrophilic, biocompatible photoluminescent quantum dots

Graphical abstract: - Highlights: • Aqueous CdSe/ZnS QDs were prepared using polymaleic anhydrides as capping ligand. • Effect of reaction temperature and time were systematically studied in the synthesis process. • Water-soluble QDs exhibited a good stability in physiological relevant environment. • The aqueous QDs were applied as biological probe to detect human embryonic stem cell. - Abstract: This paper describes a robust ligand exchange approach for preparing biocompatible CdSe/ZnS quantum dots (QDs) to make bioprobe for effective cell imaging. In this method, polymaleic anhydride (PMA) ligand are first used to replace original hydrophobic ligand (oleic acid) and form a protection shell with multiple hydrophilic groups to coat and protect CdSe/ZnS QDs. The as-prepared aqueous QDs exhibit small particle size, good colloidal stability in aqueous solutions with a wide range of pH, salt concentrations and under thermal treatment, which are necessary for biological applications. The use of this new class of aqueous QDs for effective cell imaging shows strong fluorescence signal to human embryonic stem cell, which demonstrate that PMA coated QDs are fully satisfied with the requirements of preparing high quality biological probe.
Authors:
;  [1] ;  [2] ;  [1] ;  [2] ;  [2] ;  [1]
  1. Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University, Kaifeng 475004 (China)
  2. Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055 (China)
Publication Date:
OSTI Identifier:
22341722
Resource Type:
Journal Article
Resource Relation:
Journal Name: Materials Research Bulletin; Journal Volume: 48; Journal Issue: 8; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY; CADMIUM SELENIDES; FLUORESCENCE; HEAT TREATMENTS; ION EXCHANGE; LIGANDS; PARTICLE SIZE; PHOTOLUMINESCENCE; POLYMERS; QUANTUM DOTS; SAFETY; SYNTHESIS; ZINC SULFIDES