SU-E-T-75: Commissioning Optically Stimulated Luminescence Dosimeters for Fast Neutron Therapy

Young, L; Yang, F; Sandison, G; Woodworth, D; McCormick, Z

doi:10.1118/1.4888405

Title: SU-E-T-75: Commissioning Optically Stimulated Luminescence Dosimeters for Fast Neutron Therapy

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Abstract

Purpose: Fast neutrons therapy used at the University of Washington is clinically proven to be more effective than photon therapy in treating salivary gland and other cancers. A nanodot optically stimulated luminescence (OSL) system was chosen to be commissioned for patient in vivo dosimetry for neutron therapy. The OSL-based radiation detectors are not susceptible to radiation damage caused by neutrons compared to diodes or MOSFET systems. Methods: An In-Light microStar OSL system was commissioned for in vivo use by radiating Landauer nanodots with neutrons generated from 50.0 MeV protons accelerated onto a beryllium target. The OSLs were calibrated the depth of maximum dose in solid water localized to 150 cm SAD isocenter in a 10.3 cm square field. Linearity was tested over a typical clinical dose fractionation range i.e. 0 to 150 neutron-cGy. Correction factors for transient signal fading, trap depletion, gantry angle, field size, and wedge factor dependencies were also evaluated. The OSLs were photo-bleached between radiations using a tungsten-halogen lamp. Results: Landauer sensitivity factors published for each nanodot are valid for measuring photon and electron doses but do not apply for neutron irradiation. Individually calculated nanodot calibration factors exhibited a 2–5% improvement over calibration factors computed by themore »« less

Authors:

Young, L ^[1]; Yang, F; Sandison, G ^[2]; Woodworth, D ^[3]; McCormick, Z ^[4]

UniversityWashington, Seattle, WA (United States)
University of Washington, Seattle, WA (United States)
University of California, Santa Barbara, Santa Barbara, CA (United States)
University of Nevada - Reno, Reno, Nevada (United States)

Publication Date:: Sun Jun 01 00:00:00 EDT 2014

OSTI Identifier:: 22339842

Resource Type:: Journal Article

Journal Name:: Medical Physics

Additional Journal Information:: Journal Volume: 41; Journal Issue: 6; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405

Country of Publication:: United States

Language:: English

Subject:: 07 ISOTOPES AND RADIATION SOURCES; 60 APPLIED LIFE SCIENCES; CALIBRATION; DOSEMETERS; DOSIMETRY; FAST NEUTRONS; FRACTIONATED IRRADIATION; IN VIVO; LUMINESCENCE; MOSFET; NEUTRON BEAMS; NEUTRON THERAPY; PHANTOMS; QUANTUM DOTS; RADIATION DETECTORS; RADIATION DOSES; SALIVARY GLANDS; TUNGSTEN

Citation Formats


                    Young, L, Yang, F, Sandison, G, Woodworth, D, and McCormick, Z. SU-E-T-75: Commissioning Optically Stimulated Luminescence Dosimeters for Fast Neutron Therapy.  United States: N. p., 2014. 
        Web.  doi:10.1118/1.4888405.

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                    Young, L, Yang, F, Sandison, G, Woodworth, D, & McCormick, Z. SU-E-T-75: Commissioning Optically Stimulated Luminescence Dosimeters for Fast Neutron Therapy.  United States.  https://doi.org/10.1118/1.4888405

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                    Young, L, Yang, F, Sandison, G, Woodworth, D, and McCormick, Z. 2014.  
        "SU-E-T-75: Commissioning Optically Stimulated Luminescence Dosimeters for Fast Neutron Therapy".  United States.  https://doi.org/10.1118/1.4888405.

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@article{osti_22339842,

  title        = {SU-E-T-75: Commissioning Optically Stimulated Luminescence Dosimeters for Fast Neutron Therapy},

  author       = {Young, L and Yang, F and Sandison, G and Woodworth, D and McCormick, Z},

  abstractNote = {Purpose: Fast neutrons therapy used at the University of Washington is clinically proven to be more effective than photon therapy in treating salivary gland and other cancers. A nanodot optically stimulated luminescence (OSL) system was chosen to be commissioned for patient in vivo dosimetry for neutron therapy. The OSL-based radiation detectors are not susceptible to radiation damage caused by neutrons compared to diodes or MOSFET systems. Methods: An In-Light microStar OSL system was commissioned for in vivo use by radiating Landauer nanodots with neutrons generated from 50.0 MeV protons accelerated onto a beryllium target. The OSLs were calibrated the depth of maximum dose in solid water localized to 150 cm SAD isocenter in a 10.3 cm square field. Linearity was tested over a typical clinical dose fractionation range i.e. 0 to 150 neutron-cGy. Correction factors for transient signal fading, trap depletion, gantry angle, field size, and wedge factor dependencies were also evaluated. The OSLs were photo-bleached between radiations using a tungsten-halogen lamp. Results: Landauer sensitivity factors published for each nanodot are valid for measuring photon and electron doses but do not apply for neutron irradiation. Individually calculated nanodot calibration factors exhibited a 2–5% improvement over calibration factors computed by the microStar InLight software. Transient fading effects had a significant impact on neutron dose reading accuracy compared to photon and electron in vivo dosimetry. Greater accuracy can be achieved by calibrating and reading each dosimeter within 1–2 hours after irradiation. No additional OSL correction factors were needed for field size, gantry angle, or wedge factors in solid water phantom measurements. Conclusion: OSL detectors are a useful for neutron beam in vivo dosimetry verification. Dosimetric accuracy comparable to conventional diode systems can be achieved. Accounting for transient fading effects during the neutron beam calibration is a critical component for achieving comparable accuracy.},

  doi          = {10.1118/1.4888405},

  url          = {https://www.osti.gov/biblio/22339842},
  journal      = {Medical Physics},

  issn         = {0094-2405},

  number       = 6,

  volume       = 41,

  place        = {United States},

  year         = {Sun Jun 01 00:00:00 EDT 2014},

  month        = {Sun Jun 01 00:00:00 EDT 2014}

}

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