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Title: SU-E-T-18: A New Approach To Cancer Treatment

Purpose: To assess the correlation between mean lethal radiation doses (Do) with NMR water proton spin lattice relaxation time (T1) in different phases of Hela cells. Methods: Analysis of T1 with Do was assessed in M, G1, G2 and S-phase at energies of 220 kVp, 280 kVp and 1.25 MeV (Co-60). Results: T1 against Do in M, G1, G2, and S phase at 220 kVp yield a correlation of 0.80. At 280 kVp and 1.25 MeV the correlation is 0.77 and 0.82 respectively. Conclusion: It appears that T1 value decreases from M phase (1020 ± 84 ms) to S phase (534 ± 43 ms). The Do values increases from M phase to S phase. The variation in T1 and Do in different phases of the cell cycles provide a clue to time the mitotic phase at the radiation treatment time. It appears that T1 value decreases from M phase (1020 ± 84 ms) to S phase (534 ± 43 ms). The Do values increases from M phase to S phase. The variation in T1 and Do in different phases of the cell cycles provide a clue to time the mitotic phase at the radiation treatment time.
Authors:
 [1]
  1. Radiological Physicist, Lorain, OH (United States)
Publication Date:
OSTI Identifier:
22339797
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 41; Journal Issue: 6; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CELL CYCLE; CORRELATIONS; HELA CELLS; IMAGE PROCESSING; LETHAL RADIATION DOSE; NEOPLASMS; PRODUCTIVITY; SPIN-LATTICE RELAXATION