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Title: Layered zirconium phosphonate with inorganic–organic hybrid structure: Preparation and its assembly with DNA

An aminoethoxy-functionalized zirconium phosphonate (Zr(O{sub 3}POCH{sub 2}CH{sub 2}NH{sub 2}){sub 2}·3H{sub 2}O), abbreviated as ZrRP (R=OCH{sub 2}CH{sub 2}NH{sub 2}), with layered structure has been synthesized. This layered compound possesses the characteristic of inorganic–organic hybrid, due to the covalently linked aminoethoxy in the host layer. The anion exchanged property of this zirconium phosphonate is suitable for the direct intercalation of negatively charged DNA, which is different from these reported zirconium phosphates or zirconium phosphonates. As a precursor, this prepared zirconium phosphonate was utilized to fabricate a novel DNA/ZrRP binary hybrid via a delamination-reassembly procedure. The release behavior of DNA from the DNA/ZrRP composite was investigated at different medium pH, because the combination between zirconium phosphonate sheets and DNA was pH-dependent sensitively. Moreover, the helical conformation of DNA was almost retained after the intercalation and release process. These properties of the DNA/ZrRP composite suggested the potential application of layered zirconium phosphonate as a non-viral vector in gene delivery. - Graphical abstract: The intercalation of DNA into zirconium phosphonate and the release of DNA from the interlayer of zirconium phosphonate. - Highlights: ●A layered aminoethoxy-functionalized zirconium phosphonate has been synthesized. ●DNA was intercalated directly into the prepared zirconium phosphonate. ●A novel zirconium phosphonate/DNA binarymore » hybrid was fabricated. ●DNA can be reversibly released from the interlayer of zirconium phosphonate. ●The intercalation/release processes do not induce the denaturalization of DNA.« less
Authors:
 [1] ;  [2] ;  [3] ;  [3] ;  [3]
  1. School of Chemistry and Chemical Engineering, The Key Laboratory of Coordination Chemistry of Jiangxi Province, Jinggangshan University, Ji’an 343009 (China)
  2. (China)
  3. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (China)
Publication Date:
OSTI Identifier:
22334263
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Solid State Chemistry; Journal Volume: 215; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CLATHRATES; COVALENCE; HYBRIDIZATION; PHOSPHONATES; SYNTHESIS; ZIRCONIUM; ZIRCONIUM PHOSPHATES