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Title: SU-C-9A-05: A Medical Physics Approach to the Evaluation of a New Anti-Reflux Catheter

Purpose: The Surefire Infusion System (SIS) is a coaxial microcatheter system with a pliant expanding tip designed to limit retrograde flow of administered intra-arterial embolic agents and resultant non-target embolization (NTE). A recent study suggests that the SIS may achieve relative arterial hypotension downstream to the catheter tip when compared to an end-hole catheter, potentially altering microsphere distribution. We have used a physics based approach to evaluate particulate distribution using both the SIS and standard end-hole microcatheter via a two-step same-day injection of Tc-99m MAA as a microsphere surrogate. Methods: Informed patient consent and IRB approval were obtained. Four patients with primary or secondary liver cancer underwent two sequential low-particulate infusions of Tc-99m MAA on the same day using both the SIS and a conventional end-hole catheter. Radiopharmaceutical dosages of approximately 1:8 were utilized in the first infusion relative to the second to eliminate the effect of residual activity on the images acquired after each step. SPECT imaging was obtained following each infusion, and MAA distribution was analyzed and compared. Archived fluoroscopic images confirmed near-identical catheter position for both infusions. Results: SPECT images from all four patients demonstrate qualitatively increased penetration of MAA distal to the site of infusion usingmore » the SIS when compared to a standard end-hole catheter. Quantitative evaluations corroborate these findings with some distal regions receiving between 33% to more than 200% greater relative activity when SIS was used. No appreciable NTE was identified in either patient subset. Conclusion: These preliminary data demonstrate the validity of this dual-infusion technique. Both qualitative and quantitative assessment of SPECT images and comparison with baseline contrast enhanced CT and PET/CT images indicate an improvement in MAA penetration into the target lesion with the SIS. However, the degree of improvement is highly dependent on tumor type and size. Financial support provided by Surefire Medical.« less
Authors:
;  [1]
  1. University of Tennessee Medical Center, Knoxville, TN (United States)
Publication Date:
OSTI Identifier:
22334130
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 41; Journal Issue: 6; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; COMPUTERIZED TOMOGRAPHY; IMAGES; INFUSION; LIVER; NEOPLASMS; PATIENTS; RADIOPHARMACEUTICALS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TECHNETIUM 99