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Title: Multipinhole collimator with 20 apertures for a brain SPECT application

Purpose: Several new technologies for single photon emission computed tomography (SPECT) instrumentation with parallel-hole collimation have been proposed to improve detector sensitivity and signal collection efficiency. Benefits from improved signal efficiency include shorter acquisition times and lower dose requirements. In this paper, the authors show a possibility of over an order of magnitude enhancement in photon detection efficiency (from 7.6 × 10{sup −5} to 1.6 × 10{sup −3}) for dopamine transporter (DaT) imaging of the striatum over the conventional SPECT parallel-hole collimators by use of custom-designed 20 multipinhole (20-MPH) collimators with apertures of 0.75 cm diameter. Methods: Quantifying specific binding ratio (SBR) of {sup 123}I-ioflupane or {sup 123}I-iometopane’s signal at the striatal region is a common brain imaging method to confirm the diagnosis of the Parkinson’s disease. The authors performed imaging of a striatal phantom filled with aqueous solution of I-123 and compared camera recovery ratios of SBR acquired between low-energy high-resolution (LEHR) parallel-hole collimators and 20-MPH collimators. Results: With only two-thirds of total acquisition time (20 min against 30 min), a comparable camera recovery ratio of SBR was achieved using 20-MPH collimators in comparison to that from the LEHR collimator study. Conclusions: Their systematic analyses showed that the 20-MPHmore » collimator could be a promising alternative for the DaT SPECT imaging for brain over the traditional LEHR collimator, which could give both shorter scan time and improved diagnostic accuracy.« less
Authors:
; ; ;  [1] ;  [2] ;  [3]
  1. Physics Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94107 (United States)
  2. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030 (China)
  3. Department of Radiotracer Development and Imaging Technology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94702 (United States)
Publication Date:
OSTI Identifier:
22317960
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 41; Journal Issue: 11; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ACCURACY; APERTURES; AQUEOUS SOLUTIONS; BIOLOGICAL RECOVERY; BRAIN; CAMERAS; COLLIMATORS; COMPARATIVE EVALUATIONS; DESIGN; DETECTION; DIAGNOSIS; DISEASES; DOPAMINE; DOSES; EFFICIENCY; ENERGY RECOVERY; ENHANCED RECOVERY; HOLES; IODINE 123; MATERIALS RECOVERY; PHANTOMS; PHOTONS; PRIMARY RECOVERY; RESOLUTION; SEED RECOVERY; SENSITIVITY; SIGNALS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TRANSPORT; TRITIUM RECOVERY