skip to main content

Title: Breast tumor segmentation in high resolution x-ray phase contrast analyzer based computed tomography

Purpose: Phase contrast computed tomography has emerged as an imaging method, which is able to outperform present day clinical mammography in breast tumor visualization while maintaining an equivalent average dose. To this day, no segmentation technique takes into account the specificity of the phase contrast signal. In this study, the authors propose a new mathematical framework for human-guided breast tumor segmentation. This method has been applied to high-resolution images of excised human organs, each of several gigabytes. Methods: The authors present a segmentation procedure based on the viscous watershed transform and demonstrate the efficacy of this method on analyzer based phase contrast images. The segmentation of tumors inside two full human breasts is then shown as an example of this procedure’s possible applications. Results: A correct and precise identification of the tumor boundaries was obtained and confirmed by manual contouring performed independently by four experienced radiologists. Conclusions: The authors demonstrate that applying the watershed viscous transform allows them to perform the segmentation of tumors in high-resolution x-ray analyzer based phase contrast breast computed tomography images. Combining the additional information provided by the segmentation procedure with the already high definition of morphological details and tissue boundaries offered by phase contrast imagingmore » techniques, will represent a valuable multistep procedure to be used in future medical diagnostic applications.« less
Authors:
 [1] ; ; ;  [2] ;  [3] ; ;  [4] ;  [5]
  1. European Synchrotron Radiation Facility (ESRF), Grenoble 380000, France and Department of Physics, Ludwig-Maximilians University, Garching 85748 (Germany)
  2. Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich (Germany)
  3. Department of Physics, Harvard University, Cambridge, Massachusetts 02138 (United States)
  4. Department of Physics, Ludwig-Maximilians University, Garching 85748, Germany and Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich (Germany)
  5. European Synchrotron Radiation Facility (ESRF), Grenoble 380000 (France)
Publication Date:
OSTI Identifier:
22317951
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 41; Journal Issue: 11; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; BIOMEDICAL RADIOGRAPHY; COMPUTERIZED TOMOGRAPHY; HUMAN POPULATIONS; IMAGES; MAMMARY GLANDS; NEOPLASMS; PLANT TISSUES; RESOLUTION; SPECIFICITY; WATERSHEDS