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Title: Laser Doppler vibrometry for assessment of arteriosclerosis: A first step towards validation

It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter can be estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery (FA) in the groin. However PWV can also be measured locally in the CCA, using non-invasive methods such as ultrasound (US) or laser Doppler vibrometry (LDV). Potential of the latter approach was already explored in previous research, and in this work a first step towards clinical validation is made. 50 hypertension II/III patients aged between 30 and 65 participate in the study. Patients were asked to remain sober for 4 hours prior to the measurements. The trajectory of the CCA in the neck was determined by a trained clinician guided by an US probe. 3 laser Doppler vibrometer (LDV) systems were aimed along the CCA. PWV was then calculated from the distance between beams and the time-shift between waveforms. Immediately after LDV measurements, PWV was measured with US. Additionally, carotid-femoral PWV was measured. As a validation, PWV results of the different techniques were compared with each other, and with medical background ofmore » the test subjects. Since data acquisition is still ongoing, data from only 20 patients will be discussed. No trends between measurement methods for PWV are apparent. However, a positive trend was detected between PWV as measured with LDV and blood pressure. More data, including additional experiments will be needed to verify this observation.« less
Authors:
;  [1]
  1. University of Antwerp, Laboratory of Biomedical Physics, Groenenborgerlaan 171 2020 Antwerp (Belgium)
Publication Date:
OSTI Identifier:
22311322
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1600; Journal Issue: 1; Conference: AIVELA 2014: 11. international conference on vibration measurements by laser and noncontact techniques, Ancona (Italy), 25-27 Jun 2014; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ARTERIOSCLEROSIS; BLOOD PRESSURE; CAROTID ARTERIES; COMPARATIVE EVALUATIONS; DATA ACQUISITION; DOPPLER EFFECT; ELDERLY PEOPLE; FLEXIBILITY; HYPERTENSION; LASER RADIATION; PATIENTS; VALIDATION; VELOCITY; WAVE FORMS