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Title: Detection of saliva-range glucose concentrations using organic thin-film transistors

We describe the development of a glucose sensor through direct incorporation of an enzyme (glucose oxidase) into the gate of an organic thin film transistor (OTFT). We show that glucose diffusion is the key determinant of the device response time and present a mechanism of glucose sensing in these devices that involves protonic doping of the transistor channel via enzymatic oxidation of glucose. The integrated OTFT sensor is sensitive across 4 decades of glucose concentration; a range that encompasses both the blood and salivary glucose concentration levels. As such, this work acts as a proof-of-concept for low-cost printed biosensors for salivary glucose.
Authors:
; ; ;  [1]
  1. Centre for Organic Electronics, University of Newcastle, Callaghan, New South Wales 2308 (Australia)
Publication Date:
OSTI Identifier:
22311222
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 105; Journal Issue: 4; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; BLOOD; CONCENTRATION RATIO; DETECTION; DIFFUSION; EQUIPMENT; GLUCOSE; ORGANIC SEMICONDUCTORS; OXIDASES; OXIDATION; SALIVA; SENSORS; THIN FILMS; TRANSISTORS