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Title: Radiation-induced complications in prostate cancer patients treated with radiotherapy

The purpose of the study is to determine the relationship between radiation-induced complications with dosimetric and radiobiological parameters for prostate cancer patients that underwent the conformal radiotherapy treatment. 17 prostate cancer patients that have been treated with conformal radiotherapy were retrospectively analysed. The dosimetric data was retrieved in the form of dose-volume histogram (DVH) from Radiotherapy Treatment Planning System. The DVH was utilised to derived Normal Tissue Complication Probability (NTCP) in radiobiological data. Follow-up data from medical records were used to grade the occurrence of acute gastrointestinal (GI) and genitourinary (GU) complications using Radiation Therapy Oncology Group (RTOG) scoring system. The chi-square test was used to determine the relationship between radiation-induced complication with dosimetric and radiobiological parameters. 8 (47%) and 7 (41%) patients were having acute GI and GU complications respectively. The acute GI complication can be associated with V60{sub rectum}, rectal mean dose and NTCP{sub rectum} with p-value of 0.016, 0.038 and 0.049 respectively. There are no significant relationships of acute GU complication with dosimetric and radiobiological variables. Further study can be done by increase the sample size and follow up duration for deeper understanding of the factors that effecting the GU and GI complication in prostate cancer radiotherapy.
Authors:
 [1] ; ;  [2] ;  [3] ;  [4] ;  [5]
  1. School of Applied Physics, Faculty of Sciences and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia and Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 53000 Kuala Lumpur (Malaysia)
  2. School of Applied Physics, Faculty of Sciences and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor (Malaysia)
  3. Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 53000 Kuala Lumpur (Malaysia)
  4. Department of Oncology, University Malaya Medical Center, 50603 Kuala Lumpur (Malaysia)
  5. Department of Oncology and Radiotherapy, Universiti Kebangsaan Malaysia Medical Centre, 56000 Cheras, Kuala Lumpur (Malaysia)
Publication Date:
OSTI Identifier:
22308308
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1614; Journal Issue: 1; Conference: 2014 UKM FST postgraduate colloquium, Selangor (Malaysia), 9-11 Apr 2014; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; MEDICAL RECORDS; NEOPLASMS; PATIENTS; PROSTATE; RADIATION DOSES; RADIOTHERAPY; RECTUM; VANADIUM 60