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Title: Iron and aluminum interaction with amyloid-beta peptides associated with Alzheimer’s disease

An elevation in the concentration of heavy metal ions in Alzheimer’s disease (AD) brain has been demonstrated in many studies. Aβ precipitation and toxicity in AD brains seem to be caused by abnormal interactions with neocortical metal ions, especially iron, copper, zinc, and aluminum [1–3]. There is increasing evidence that iron and aluminum ions are involved in the mechanisms that underlie the neurodegenerative diseases [4,5]. However, evidence was brought to demonstrate that some Aβ fragments, at physiological pH, are not able to form binary complexes with Fe(III) ions of sufficient stability to compete with metal hydroxide precipitation [6]. On the contrary, multiple metal ions are known to interact with Aβ peptides [7]. Consequently, we investigated here the interaction of Fe(II/III) and Al(III) ions with some amyloid-β peptides and fragments that results in peptide aggregation and fibrillation [8,9]. Infrared spectroscopy, atomic force microscopy, scanning electron microscopy, electrophoresis and mass spectrometry demonstrated conformational changes of peptides in the presence of such metals.
Authors:
;  [1] ; ;  [2]
  1. Alexandru Ioan Cuza University of Iasi, 11 Carol I, Iasi 700506 (Romania)
  2. Petru Poni Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi 700487 (Romania)
Publication Date:
OSTI Identifier:
22307975
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1618; Journal Issue: 1; Conference: ICCMSE 2014: International conference on computational methods in science and engineering 2014, Athens (Greece), 4-7 Apr 2014; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; 60 APPLIED LIFE SCIENCES; ABSORPTION SPECTROSCOPY; AGGLOMERATION; ALUMINIUM; ALUMINIUM IONS; ATOMIC FORCE MICROSCOPY; BRAIN; CONCENTRATION RATIO; COPPER; ELECTROPHORESIS; HEAVY METALS; HYDROXIDES; INFRARED SPECTRA; IRON; MASS SPECTROSCOPY; NERVOUS SYSTEM DISEASES; PEPTIDES; PRECIPITATION; SCANNING ELECTRON MICROSCOPY; ZINC