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Title: Dynamic nuclear renography kinetic analysis: Four-compartment model for assessing kidney function

Dynamic nuclear renography method produces TACs of kidneys and bladder. Multiple TACs data can be further analyzed to obtain the overview of urinary system's condition. Tracer kinetic analysis was performed using four-compartment models. The system's model consist of four irreversible compartment with four transport constants (k1, k2, k3 and k4). The mathematical expressions of tracer's distributions is fitted to experimental data (TACs) resulting in model constants. This transport constants represent the urinary system behavior, and later can be used for analyzing system's condition. Different intervals of kinetics parameter are clearly shown by abnormal system with respect to the normal one. Furthermore, the system with delayed uptake has 82% lower uptake parameters (k1 and k2) than normal one. Meanwhile, the system with prolonged clearance time has its kinetics parameters k3 or k4 lower than the others. This model is promising for quantitatively describe urinary system's function especially if supplied with more data.
Authors:
;  [1]
  1. Department of Physics, Nuclear Physics and Biophysics Research Group, Institut Teknologi Bandung, Bandung (Indonesia)
Publication Date:
OSTI Identifier:
22307862
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1615; Journal Issue: 1; Conference: ICANSE 2013: 4. international conference on advances in nuclear science and engineering, Denpasar, Bali (Indonesia), 16-19 Sep 2013; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; AVAILABILITY; BLADDER; CLEARANCE; KIDNEYS; MATHEMATICAL MODELS; RENOGRAPHY; TRACE AMOUNTS; UPTAKE