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Title: Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy

Over the last decade, the development and application of nanotechnology in cancer detection, diagnosis, and therapy have been widely reported. Engineering of vehicles for the simultaneous delivery of chemo- and radiotherapeutics increases the effectiveness of the therapy and reduces the dosage of each individual drug required to produce an observable therapeutic response. We here developed a novel chemoradiotherapeutic 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid coated/uncoated platinum drug loaded, holmium-containing, wrinkled mesoporous silica nanoparticle. The materials were characterized with TEM, FTIR, {sup 1}H NMR, energy dispersive x-ray, inductively coupled plasma-mass spectrometry, and zeta potential measurements. In vitro platinum drug release from both lipid coated and uncoated chemoradiotherapeutic wrinkled mesoporous silica are reported. Various kinetic models were used to analyze the release kinetics. The radioactivity of the chemoradiotherapeutic nanocarriers was measured after neutron-activation.
Authors:
;  [1] ; ; ;  [2]
  1. Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, Texas 75080 (United States)
  2. Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, Texas 76107 (United States)
Publication Date:
OSTI Identifier:
22303415
Resource Type:
Journal Article
Resource Relation:
Journal Name: APL Materials; Journal Volume: 2; Journal Issue: 11; Other Information: (c) 2014 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; ICP MASS SPECTROSCOPY; NANOSTRUCTURES; NEOPLASMS; NEUTRONS; NUCLEAR MAGNETIC RESONANCE; PLATINUM; SILICA; THERAPY; TRANSMISSION ELECTRON MICROSCOPY