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Title: Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles

We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF{sub 4}:Yb{sup 3+}/Er{sup 3+}@NaYF{sub 4} upconverting nanoparticles were synthesized through a stoichiometric method. The Yb{sup 3+}/Er{sup 3+} sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information.
Authors:
 [1] ;  [2] ;  [3] ; ; ; ;  [1]
  1. Department of Physics, Lund University, P.O. Box 118, SE-221 00 Lund (Sweden)
  2. (Sweden)
  3. (UCMR), Umeå University, SE-901 87 Umeå (Sweden)
Publication Date:
OSTI Identifier:
22283295
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 104; Journal Issue: 7; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; COMPARATIVE EVALUATIONS; CRYSTAL DOPING; ERBIUM IONS; FLUORESCENCE; NANOSTRUCTURES; PARTICLES; SODIUM COMPOUNDS; TOMOGRAPHY; YTTERBIUM IONS; YTTRIUM FLUORIDES