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Title: Thermal property and assessment of biocompatibility of poly(lactic-co-glycolic) acid/graphene nanocomposites

Polymer-matrix nanocomposites based on Poly(lactic-co-glycolic) acid (PLGA) and Graphene platelets (GNPs) were studied. GNPs, nanomaterials with a 2D flat surface, were chosen with or without chemical modification in PLGA/GNP nanocomposites and their microstructure, thermal property, and their compatibility as scaffolds for cell growth were investigated. PLGA/GNP nanocomposites (0, 1, and 5 wt. % of GNPs) were prepared using a solution based technique. Transmission electron microscopy, X-ray diffraction, Differential scanning calorimeter, and Thermogravimetric analyzer were used to analyze morphology and thermal properties. This work demonstrated the role of GNPs flat surface to provide a favorable platform resulting in an enhanced PLGA crystallization. Functionalized GNPs suppress both the thermal stability and the crystallization of PLGA. Finally, to determine the potential usefulness of these scaffolds for biomedical applications, mammalian cells were cultured on various PLGA/GNP nanocomposites (0, 1, and 5 wt. % GNPs). 1 wt. % PLGA/GNP nanocomposites showed better biocompatibility for cell growth with/without graphenes functionalization compared to pure PLGA and 5 wt. % PLGA/GNP. The function of GNPs in PLGA/GNPs (1 wt. %) composites is to provide a stage for PLGA crystallization where cell growth is favored. These results provide strong evidence for a new class of materials that could be important for biomedical applications.
Authors:
 [1] ; ;  [1] ;  [2] ;  [3] ; ; ;  [4]
  1. Texas Center for Superconductivity, University of Houston, Houston, Texas-77204 (United States)
  2. (United States)
  3. Department of Mechanical Engineering, University of Houston, Texas, Texas-77204 (United States)
  4. Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas-77555 (United States)
Publication Date:
OSTI Identifier:
22278132
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Applied Physics; Journal Volume: 115; Journal Issue: 5; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; CALORIMETRY; COMPARATIVE EVALUATIONS; COMPOSITE MATERIALS; CRYSTALLIZATION; DIFFERENTIAL THERMAL ANALYSIS; GLYCOLIC ACID; GRAPHENE; MICROSTRUCTURE; MORPHOLOGY; NANOSTRUCTURES; ORGANIC POLYMERS; PHASE STABILITY; SURFACES; THERMAL GRAVIMETRIC ANALYSIS; THERMODYNAMIC PROPERTIES; TRANSMISSION ELECTRON MICROSCOPY; X-RAY DIFFRACTION