Thermal property and assessment of biocompatibility of poly(lactic-co-glycolic) acid/graphene nanocomposites

Journal Article · Fri Feb 07 00:00:00 EST 2014 · Journal of Applied Physics

DOI:https://doi.org/10.1063/1.4864263· OSTI ID:22278132

Rusakova, Irene; Chu, Wei-Kan ^[1]; Haleh, Ardebili ^[2]; Luisi, Jonathan; Panova, Neli I.; Laezza, Fernanda ^[3]

---

1. Texas Center for Superconductivity, University of Houston, Houston, Texas-77204 (United States)
2. Department of Mechanical Engineering, University of Houston, Texas, Texas-77204 (United States)
3. Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas-77555 (United States)

Polymer-matrix nanocomposites based on Poly(lactic-co-glycolic) acid (PLGA) and Graphene platelets (GNPs) were studied. GNPs, nanomaterials with a 2D flat surface, were chosen with or without chemical modification in PLGA/GNP nanocomposites and their microstructure, thermal property, and their compatibility as scaffolds for cell growth were investigated. PLGA/GNP nanocomposites (0, 1, and 5 wt. % of GNPs) were prepared using a solution based technique. Transmission electron microscopy, X-ray diffraction, Differential scanning calorimeter, and Thermogravimetric analyzer were used to analyze morphology and thermal properties. This work demonstrated the role of GNPs flat surface to provide a favorable platform resulting in an enhanced PLGA crystallization. Functionalized GNPs suppress both the thermal stability and the crystallization of PLGA. Finally, to determine the potential usefulness of these scaffolds for biomedical applications, mammalian cells were cultured on various PLGA/GNP nanocomposites (0, 1, and 5 wt. % GNPs). 1 wt. % PLGA/GNP nanocomposites showed better biocompatibility for cell growth with/without graphenes functionalization compared to pure PLGA and 5 wt. % PLGA/GNP. The function of GNPs in PLGA/GNPs (1 wt. %) composites is to provide a stage for PLGA crystallization where cell growth is favored. These results provide strong evidence for a new class of materials that could be important for biomedical applications.

• OSTI ID: 22278132
• Journal Information: Journal of Applied Physics, Vol. 115, Issue 5; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0021-8979
• Country of Publication: United States
• Language: English

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
CALORIMETRY
COMPARATIVE EVALUATIONS
COMPOSITE MATERIALS
CRYSTALLIZATION
DIFFERENTIAL THERMAL ANALYSIS
GLYCOLIC ACID
GRAPHENE
MICROSTRUCTURE
MORPHOLOGY
NANOSTRUCTURES
ORGANIC POLYMERS
PHASE STABILITY
SURFACES
THERMAL GRAVIMETRIC ANALYSIS
THERMODYNAMIC PROPERTIES
TRANSMISSION ELECTRON MICROSCOPY
X-RAY DIFFRACTION