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Title: Gold nanoparticles for cancer detection and treatment: The role of adhesion

This paper presents the results of an experimental study of the effects of adhesion between gold nanoparticles and surfaces that are relevant to the potential applications in cancer detection and treatment. Adhesion is measured using a dip coating/atomic force microscopy (DC/AFM) technique. The adhesion forces are obtained for dip-coated gold nanoparticles that interact with peptide or antibody-based molecular recognition units (MRUs) that attach specifically to breast cancer cells. They include MRUs that attach specifically to receptors on breast cancer cells. Adhesion forces between anti-cancer drugs such as paclitaxel, and the constituents of MRU-conjugated Au nanoparticle clusters, are measured using force microscopy techniques. The implications of the results are then discussed for the design of robust gold nanoparticle clusters and for potential applications in localized drug delivery and hyperthermia.
Authors:
 [1] ;  [2] ;  [3] ; ;  [4] ;  [5] ;  [4] ;  [6] ;  [2] ;  [1] ;  [2] ;  [7]
  1. Princeton Institute for Science and Technology of Materials (PRISM), Princeton University, 70 Prospect Street, Princeton, New Jersey 08544 (United States)
  2. (United States)
  3. Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)
  4. African University of Science and Technology (AUST), Kilometer 10, Airport Road, Abuja, Federal Capital Territory (Nigeria)
  5. (SHESTCO), Gwagwalada, Abuja, Federal Capital Territory (Nigeria)
  6. Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544 (United States)
  7. (AUST), Kilometer 10, Airport Road, Abuja, Federal Capital Territory (Nigeria)
Publication Date:
OSTI Identifier:
22278000
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Applied Physics; Journal Volume: 115; Journal Issue: 8; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; 60 APPLIED LIFE SCIENCES; ADHESION; ANTIBODIES; ATOMIC FORCE MICROSCOPY; DELIVERY; DIP COATING; DRUGS; GOLD; HYPERTHERMIA; MAMMARY GLANDS; NANOSTRUCTURES; NEOPLASMS; PARTICLES; PEPTIDES; RECEPTORS