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Title: Engineering of gadofluoroprobes: Broad-spectrum applications from cancer diagnosis to therapy

The engineering of the Gadolinium based nanostructures have been demonstrated in this paper. Nanostructures of α-Gd{sub 2}S{sub 3} exhibit a unique transition between ferromagnetic state and paramagnetic state of the system. It was demonstrated that their properties could be tuned for a wide range of applications ranging from hyperthermia to Magnetic Resonance Imaging, owing to their magnetic moments and large relaxivities. Metallic Gd nanoparticles obtained by reduction method were employed for cancer imaging in mice. The Gd nanoparticles were coated with Curcumin and their biomedical implications in the field of simultaneous diagnosis and therapy of cancer and related diseases has been discussed.
Authors:
 [1] ;  [2] ;  [1] ;  [2] ;  [3] ; ;  [4] ;  [5] ;  [1] ;  [2] ;  [2]
  1. Nanotechnology Application Centre, University of Allahabad, Allahabad 211002 (India)
  2. (India)
  3. Department of Pathology, KGMU, Lucknow (India)
  4. Centre for Cellular and Molecular Biology, Hyderabad (India)
  5. Department of Physics, Michigan Technological University, Michigan 49931-1295 (United States)
Publication Date:
OSTI Identifier:
22275768
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 104; Journal Issue: 2; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; 77 NANOSCIENCE AND NANOTECHNOLOGY; BIOMEDICAL RADIOGRAPHY; CURCUMIN; GADOLINIUM; GADOLINIUM SULFIDES; MAGNETIC MOMENTS; NANOSTRUCTURES; NEOPLASMS