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Title: Study of polyvinyl alcohol nanofibrous membrane by electrospinning as a magnetic nanoparticle delivery approach

Electrospinning technique was used to fabricate polyvinyl alcohol (PVA)-based magnetic biodegradable nanofibers. PVA solution was mixed with ferrofluid or magnetic nanoparticles (MNPs) powder and formed two individual nanofibrous membranes (PVA/ferrofluid and PVA/MNPs powder) by electrospinning. The surface morphology of the nanofibrous membrane was characterized by scanning electron microscopy and the magnetic properties were measured by vibrating sample magnetometer. Macrophages (RAW 264.7) were co-cultured with the nanofibrous membranes for 12, 24, and 48 h and exhibited good cell viability (>95%). Results showed that the PVA fibers would be degraded and the embedded Fe{sub 3}O{sub 4} nanoparticles would be released and delivered to cells.
Authors:
; ;  [1] ;  [2] ;  [3] ;  [4] ;  [1] ;  [5]
  1. Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu, Taiwan (China)
  2. Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan (China)
  3. Department of Applied Physics, National Ping Tung University of Education, Pingtung, Taiwan (China)
  4. Center of Nanoscience and Nanotechnology, National Chung Hsing University, Taichung, Taiwan (China)
  5. (China)
Publication Date:
OSTI Identifier:
22273722
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Applied Physics; Journal Volume: 115; Journal Issue: 17; Conference: 55. annual conference on magnetism and magnetic materials, Atlanta, GA (United States), 14-18 Nov 2010; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 60 APPLIED LIFE SCIENCES; FIBERS; IRON OXIDES; MACROPHAGES; MAGNETIC MATERIALS; MAGNETIC PROPERTIES; MEMBRANES; MORPHOLOGY; NANOSTRUCTURES; PARTICLES; POWDERS; PVA; SCANNING ELECTRON MICROSCOPY; SURFACES; VIABILITY; VIBRATING SAMPLE MAGNETOMETERS