skip to main content

Title: Hybrid radiosity-SP{sub 3} equation based bioluminescence tomography reconstruction for turbid medium with low- and non-scattering regions

To provide an ideal solution for a specific problem of gastric cancer detection in which low-scattering regions simultaneously existed with both the non- and high-scattering regions, a novel hybrid radiosity-SP{sub 3} equation based reconstruction algorithm for bioluminescence tomography was proposed in this paper. In the algorithm, the third-order simplified spherical harmonics approximation (SP{sub 3}) was combined with the radiosity equation to describe the bioluminescent light propagation in tissues, which provided acceptable accuracy for the turbid medium with both low- and non-scattering regions. The performance of the algorithm was evaluated with digital mouse based simulations and a gastric cancer-bearing mouse based in situ experiment. Primary results demonstrated the feasibility and superiority of the proposed algorithm for the turbid medium with low- and non-scattering regions.
Authors:
; ; ;  [1]
  1. School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071 (China)
Publication Date:
OSTI Identifier:
22271234
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Applied Physics; Journal Volume: 115; Journal Issue: 2; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ALGORITHMS; ANIMAL TISSUES; APPROXIMATIONS; BIOLUMINESCENCE; COMPUTERIZED SIMULATION; DIAGNOSIS; DIAGNOSTIC USES; LIGHT TRANSMISSION; MICE; NEOPLASMS; PERFORMANCE; SCATTERING; SPHERICAL HARMONICS; TOMOGRAPHY