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Title: Generation of drugs coated iron nanoparticles through high energy ball milling

The iron nanoparticles coated with oleic acid and drugs such as folic acid/Amoxicillin were synthesized by high energy ball milling and characterized by X-ray diffraction, Transmission electron microscope, zeta potential, dynamic light scattering, Fourier Transform Infra red (FT-IR) measurements, and thermo gravimetric analysis (TGA). FT-IR and TGA measurements show good adsorption of drugs on oleic acid coated nanoparticles. Magnetic measurements indicate that saturation magnetization is larger for amoxicillin coated particles compared to folic acid coated particles. The biocompatibility of the magnetic nanoparticles prepared was evaluated by in vitro cytotoxicity assay using L929 cells as model cells.
Authors:
;  [1] ;  [2] ; ; ;  [3]
  1. Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai 600036 (India)
  2. Defence Metallurgical Research Laboratory, Hyderabad 500058 (India)
  3. Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036 (India)
Publication Date:
OSTI Identifier:
22271128
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Applied Physics; Journal Volume: 115; Journal Issue: 12; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; 77 NANOSCIENCE AND NANOTECHNOLOGY; ADSORPTION; COMPARATIVE EVALUATIONS; FOLIC ACID; FOURIER TRANSFORMATION; INFRARED SPECTRA; IRON; LIGHT SCATTERING; MAGNETIZATION; MILLING; NANOSTRUCTURES; OLEIC ACID; PARTICLES; THERMAL GRAVIMETRIC ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; X-RAY DIFFRACTION