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Title: Electron spin resonance studies on reduction process of nitroxyl spin radicals used in molecular imaging

The Electron spin resonance studies on the reduction process of nitroxyl spin probes were carried out for 1mM {sup 14}N labeled nitroxyl radicals in pure water and 1 mM concentration of ascorbic acid as a function of time. The electron spin resonance parameters such as signal intensity ratio, line width, g-value, hyperfine coupling constant and rotational correlation time were determined. The half life time was estimated for 1mM {sup 14}N labeled nitroxyl radicals in 1 mM concentration of ascorbic acid. The ESR study reveals that the TEMPONE has narrowest line width and fast tumbling motion compared with TEMPO and TEMPOL. From the results, TEMPONE has long half life time and high stability compared with TEMPO and TEMPOL radical. Therefore, this study reveals that the TEMPONE radical can act as a good redox sensitive spin probe for molecular imaging.
Authors:
;  [1] ;  [2]
  1. Department of Physics, NMSSVN College, Nagamalai, Madurai-625019, Tamilnadu (India)
  2. Department of Chemistry, NMSSVN College, Nagamalai, Madurai-625019, Tamilnadu (India)
Publication Date:
OSTI Identifier:
22269308
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1591; Journal Issue: 1; Conference: 58. DAE solid state physics symposium 2013, Patiala, Punjab (India), 17-21 Dec 2013; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; ASCORBIC ACID; COUPLING CONSTANTS; ELECTRON SPIN RESONANCE; LINE WIDTHS; NITROGEN 14; NITROXYL RADICALS; PROBES; SPIN; STABILITY; TIME DEPENDENCE