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Title: Nanoparticle preparation of Mefenamic acid by electrospray drying

Nanoparticles preparation of Mefenamic acid (MA) by using an electrospray drying method was conducted in this study. Electrospray drying is a process that uses electrostatic force to disperse a conductive liquid stream into fine charged droplets through the coulomb fission of charges in the liquid and finally dry into fine particles. Electrospray drying modes operation usually in Taylor cone jet, and it was formed by controlling applied voltage and liquid flow rate. A conductive liquid (2.77–8.55μScm{sup −1}) which is MA solution was prepared by using acetone with concentration 0.041 and 0.055 M before pumping at a flow rate of 3–6ml/h. By applying the applied voltage at 1.3–1.5 kV, Taylor cone jet mode was formed prior to the electrospray. During electrospray drying process, solvent evaporation from the droplet was occurring that leads to coulomb disruption and may generate to nanoparticles. The dried nanoparticles were collected on a grounded substrate that was placed at varying distance from the electrospray. MA particle with size range of 100–400 nm were produced by electrospray drying process. Characterization of particles by using X-ray diffractometry (XRD) and differential scanning calorimetry (DSC) show that particles formed into polymorph I.
Authors:
; ;  [1] ;  [2] ;  [3]
  1. Faculty Of Chemical Engineering, Universiti Teknologi Mara (UiTM), 40450 Shah Alam, Selangor (Malaysia)
  2. Food and Process Department, Faculty of Engineering, Universiti Putra Malaysia (UPM), 43400 UPM Serdang, Selangor (Malaysia)
  3. Kulliyyah of Pharmacy, International Islamic University Malaysia, P.O Box 141, 25710, Kuantan, Pahang (Malaysia)
Publication Date:
OSTI Identifier:
22266018
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1586; Journal Issue: 1; Conference: NNS2013: 5. nanoscience and nanotechnology symposium, Surabaya (Indonesia), 23-25 Oct 2013; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 77 NANOSCIENCE AND NANOTECHNOLOGY; ACETONE; CALORIMETRY; DROPLETS; ELECTRIC POTENTIAL; EVAPORATION; LIQUID FLOW; LIQUIDS; NANOSTRUCTURES; SOLVENTS; SUBSTRATES; X-RAY DIFFRACTION