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Title: Maximizing dosimetric benefits of IMRT in the treatment of localized prostate cancer through multicriteria optimization planning

We examine the quality of plans created using multicriteria optimization (MCO) treatment planning in intensity-modulated radiation therapy (IMRT) in treatment of localized prostate cancer. Nine random cases of patients receiving IMRT to the prostate were selected. Each case was associated with a clinically approved plan created using Corvus. The cases were replanned using MCO-based planning in RayStation. Dose-volume histogram data from both planning systems were presented to 2 radiation oncologists in a blinded evaluation, and were compared at a number of dose-volume points. Both physicians rated all 9 MCO plans as superior to the clinically approved plans (p<10{sup −5}). Target coverage was equivalent (p = 0.81). Maximum doses to the prostate and bladder and the V50 and V70 to the anterior rectum were reduced in all MCO plans (p<0.05). Treatment planning time with MCO took approximately 60 minutes per case. MCO-based planning for prostate IMRT is efficient and produces high-quality plans with good target homogeneity and sparing of the anterior rectum, bladder, and femoral heads, without sacrificing target coverage.
Authors:
;  [1] ;  [2] ;  [3] ;  [1] ;  [2] ;  [1] ;  [2]
  1. Harvard Medical School, Boston, MA (United States)
  2. (United States)
  3. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States)
Publication Date:
OSTI Identifier:
22262826
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Dosimetry; Journal Volume: 38; Journal Issue: 3; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; EXTERNAL BEAM RADIATION THERAPY; NEOPLASMS; OPTIMIZATION; PLANNING; PROSTATE; RADIATION DOSES