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Title: Biomimetic synthesis of modified calcium phosphate fine powders and their in vitro studies

Biomimetic approach and subsequent high-temperature treatment were used to synthesize ion modified calcium phosphate fine powders. Thus, using Simulated Body Fluid (SBF) as an ion modifier, a bi-phase mixture of ion modified β-tricalcium phosphate and hydroxyapatite (β-TCP + HA) was prepared. The use of SBF electrolyte solution enriched with Mg{sup 2+} or Zn{sup 2+} yielded monophase β-tricalcium phosphate additionally modified with Mg{sup 2+} or Zn{sup 2+} (Mg-β-TCP or Zn-β-TCP). The in vitro behavior of the prepared powders on cell viability and proliferation of murine BALB/c 3T3 fibroblasts and of human Lep 3 cells was studied by MTT test assays and Mosmann method after 72 h incubation. The relative cell viability was calculated.
Authors:
; ; ; ;  [1] ; ;  [2]
  1. Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 11, 1113 Sofia (Bulgaria)
  2. Institute of Experimental Morphology, Pathology and Anthropology with Museum, BAS, Acad. G. Bonchev Str., Bl. 25, Sofia (Bulgaria)
Publication Date:
OSTI Identifier:
22261691
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1569; Journal Issue: 1; Conference: 3. international advances in applied physics and materials science congress, Antalya (Turkey), 24-28 Apr 2013; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES; BODY FLUIDS; CALCIUM PHOSPHATES; FIBROBLASTS; IN VITRO; MAGNESIUM IONS; POWDERS; SIMULATION; SYNTHESIS; ZINC IONS