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Title: Nonlinear simulations to optimize magnetic nanoparticle hyperthermia

Magnetic nanoparticle hyperthermia is an attractive emerging cancer treatment, but the acting microscopic energy deposition mechanisms are not well understood and optimization suffers. We describe several approximate forms for the characteristic time of NĂ©el rotations with varying properties and external influences. We then present stochastic simulations that show agreement between the approximate expressions and the micromagnetic model. The simulations show nonlinear imaginary responses and associated relaxational hysteresis due to the field and frequency dependencies of the magnetization. This suggests that efficient heating is possible by matching fields to particles instead of resorting to maximizing the power of the applied magnetic fields.
Authors:
;  [1]
  1. Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755 (United States)
Publication Date:
OSTI Identifier:
22257750
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 104; Journal Issue: 10; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 62 RADIOLOGY AND NUCLEAR MEDICINE; HEATING; HYPERTHERMIA; HYSTERESIS; MAGNETIC FIELDS; NANOSTRUCTURES; NEOPLASMS; PARTICLES; STOCHASTIC PROCESSES