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Title: Stimuli responsive magnetic nanogels for biomedical application

We report the synthesis and characterization of magnetic nanogels based on magnetite nanoparticles sterically stabilized by double layer oleic acid in water carrier and chemically cross linked poly (N-isopropylacril amide) (pNIPA) and poly (acrylic acid) (pAAc). In this structure the magnetite nanoparticles are attached to the flexible network chain by adhesive forces, resulting in a direct coupling between magnetic and elastic properties. Stable water suspensions of dual responsive magnetic nanogels based on temperature-responsive N-isopropyl acryl amide, pH responsive acrylic acid were obtained. The FTIR spectra of p(NIPA-AAc) ferrogel samples, showed the absorption region of the specific chemical groups associated with pNIPA, pAAc and the Fe{sub 3}O{sub 4} magnetic nanoparticles. The morphology and the structure of the as prepared materials were confirmed by transmission electron microscopy (TEM) and the size distribution was determined by dynamic light scattering (DLS). The magnetic microgels have high magnetization and superparamagnetic behaviour being suitable materials for biomedical application.
Authors:
; ;  [1] ; ; ;  [2]
  1. National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath, 400293 Cluj-Napoca (Romania)
  2. Romanian Academy, Timisoara Branch, Magnetic Fluids Laboratory, Timisoara (Romania)
Publication Date:
OSTI Identifier:
22257185
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1565; Journal Issue: 1; Conference: PIM 2013: International conference on processes in isotopes and molecules, Cluj Napoca (Romania), 25-27 Sep 2013; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; ACRYLIC ACID; ELASTICITY; FERRITES; FOURIER TRANSFORMATION; INFRARED SPECTRA; IRON OXIDES; LIGHT SCATTERING; MAGNETITE; NANOSTRUCTURES; OLEIC ACID; PARTICLES; SUPERPARAMAGNETISM; TRANSMISSION ELECTRON MICROSCOPY