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Title: Nanoscale characterization of the biomechanical properties of collagen fibrils in the sclera

We apply the PeakForce Quantitative Nanomechanical Property Mapping (PFQNM) atomic force microscopy mode for the investigation of regional variations in the nanomechanical properties of porcine sclera. We examine variations in the collagen fibril diameter, adhesion, elastic modulus and dissipation in the posterior, equatorial and anterior regions of the sclera. The mean fibril diameter, elastic modulus and dissipation increased from the posterior to the anterior region. Collagen fibril diameter correlated linearly with elastic modulus. Our data matches the known macroscopic mechanical behavior of the sclera. We propose that PFQNM has significant potential in ocular biomechanics and biophysics research.
Authors:
 [1] ;  [2] ; ;  [3]
  1. Institute of Physics, Università Cattolica del Sacro Cuore, Largo F.Vito 1, 00168 Rome (Italy)
  2. Centre for Engineering Dynamics, School of Engineering, Brownlow Hill, Liverpool, L69 3GH (United Kingdom)
  3. Centre for Materials and Structures, School of Engineering, Brownlow Hill, Liverpool, L69 3GH (United Kingdom)
Publication Date:
OSTI Identifier:
22257032
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 104; Journal Issue: 10; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 60 APPLIED LIFE SCIENCES; ATOMIC FORCE MICROSCOPY; BIOPHYSICS; COLLAGEN; EYES; NANOSTRUCTURES