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Title: A method to measure nanomechanical properties of biological objects

We postulate that one will be able to quantitatively infer changes in the mechanical properties of proteins, cells, and other biological objects (BO) by measuring the shifts of several thermally excited resonance frequencies of atomic force microscopy cantilevers in contact with BOs. Here, we provide a method to extract spring constants and molecular damping factors of BOs in biologically relevant phosphate buffered saline medium and using compliant AFM cantilevers with a small aspect ratio (a ratio of length to width)
Authors:
;  [1]
  1. Department of Physics, Kansas State University, Manhattan, Kansas 66506 (United States)
Publication Date:
OSTI Identifier:
22253215
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 103; Journal Issue: 26; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY; ASPECT RATIO; ATOMIC FORCE MICROSCOPY; LENGTH; MECHANICAL PROPERTIES; PHOSPHATES; PROTEINS; SPRINGS